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澳洲昆士兰大学代写:谷胱甘肽

Keywords:澳洲昆士兰大学代写:谷胱甘肽

谷胱甘肽的稳态控制状态通过连续自我调节来平衡GSH的生产,从GSSG中进行再加工,其使用是GSH合成酶、GSH还原酶、过氧化物酶、转移酶、transhydrogenases和transpeptidases等酶的功能。Cysteinyl moiety是谷胱甘肽的功能成分,它提供了硫醇反应基团,它负责蛋白质结构和功能的维持,通过蛋白质二硫键还原,控制蛋白质的生产和分解,维持免疫功能,抵御氧化损伤,去除反应性化学物质。谷胱甘肽的代谢和功能直接由谷胱甘肽的结构元素决定。谷胱甘肽是谷氨酸和c -末端甘氨酸存在的-羧基肽键。所有的哺乳动物细胞产生GSH (Meister和Tate, 1976)和主要的生物合成位点是肝脏(Deleve和Kaplowitz, 1991)。GSH的产生发生在细胞的细胞质中,其分解发生在细胞外;生产涉及由GSH合成酶催化的两相反应和-谷氨酰半胱氨酸合成酶,每一摩尔GSH中使用2mol的三磷酸腺苷(ATP),而分解过程则是由在上皮组织表面的-谷氨酰转肽酶和二肽酶催化。
澳洲昆士兰大学代写:谷胱甘肽
The homeostatical control status of glutathione by continuous self adjusting to equilibrate GSH production, its reprocessing from GSSG and its usage is a function of enzymes such as GSH synthetase, GSH reductase, peroxidises, transferases, transhydrogenases and transpeptidases. Cysteinyl moiety is the functional element of glutathione that provides the thiol reactive group which is liable for the sustenance of protein structure and functions through proteins disulfide linkages reduction, controlling of production and breakdown of protein, sustenance of immune function, defence against oxidative injury, removal of reactive chemicals. The metabolism and function of glutathione is directly decided by structural elements of glutathione which are γ-carboxyl peptide linkages of glutamate and C-terminal glycine presence. All mammalian cells produces GSH (Meister and Tate, 1976) and major site of biosynthesis is the liver ( Deleve and Kaplowitz, 1991). The production of GSH occurs in the cytosol of cell and its breakdown takes place outside the cell; production involves a two phase reaction catalyzed by GSH synthetase and γ-glutamylcysteine synthetase that uses two moles of adenosine triphosphate(ATP) per one mole of GSH while the breakdown are catalyzed by γ-glutamyl transpeptidase and dipeptidases present on the top surface of epithelial tissues. 

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